Sibutramine in treating obesity: You must know more about sibutramine!!!
What is sibutramine?
Sibutramine is a medication that assists with weight-loss by altering neurotransmitters within 
the brain. Neurotransmitters are chemicals that are produced and released by nerves in order to communicate with other nerves. Released neurotransmitters may attach to other nerves or they may be taken up again by the nerves that release them, a process termed reuptake. Sibutramine blocks the reuptake of the neurotransmitters dopamine, norepinephrine, and serotonin. Blocking the reuptake of neurotransmitters alters the balance of neurotransmitters within the nerve cells and thereby affect nerve function and interaction.
Meridia is found to be highly effective in the treatment of obesity as the medication is able to bring down the additional flab in the body in a gradual way spread over a period of time. If the weight loss program is accompanied by a proper diet and right medication like Meridia it leads to a definite reduction in body weight and also opens up the clear passage of healthy life. Obesity is a commonly reported problem affecting many people and it’s also understood by the patients how difficult it is shed the excess weight. When the body has excess weight it becomes a persisting problem for the individual to perform even simple tasks. With obesity as the main ailment, other issues also step into the body and make the affected person suffer on the whole.
Sibutramine Mechanism of Action
- Sibutramine (the active ingredient in Meridia) is a powerful central nervous system stimulant similar to amphetamines, and chemically related to Phentermine ( the active ingredient in the weight loss drug Adipex).
- Sibutramine works by increasing Serotonin and Norepinephrine levels in the brain, which leads to appetite suppression.
- This drug was initially developed as an antidepressant, and later approved by the FDA for the treatment of obesity.
How does sibutramine works?
Sibutramine offers three types of benefit in weight management: by enhancing weight loss, by improving weight maintenance and by reducing the comorbidities of obesity. The clinical effects of sibutramine are explained through its known mode of action as a serotonin (5-HT) and noradrenaline reuptake inhibitor (SNRI). This dual mechanism of action results in two synergistic physiological effects–a reduction in energy intake and an increase in energy expenditure, which combine to promote and maintain weight loss.
How to Use Sibutramine hydrochloride?
Sibutramine is usually taken 10-15mg a time,once daily. Follow your doctor's instructions.Your doctor may occasionally change your dose to make sure you get the best results.Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Sibutramine can be taken with or without food.You should lose at least 4 pounds during the first 4 weeks of taking sibutramine and eating a low calorie diet. Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks.
Sibutramine should not be taken for longer than 2 years.Store at room temperature away from moisture, heat, and light.Do not share sibutramine with another person. Keep the medication in a place where others cannot get to it.
Your blood pressure and pulse will need to be checked often. Visit your doctor regularly.Overdose symptoms may include headache, dizziness, and fast heart rate.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Sibutramine Dosage
Usual Adult Dose for Obesity
Sibutramine was voluntarily withdrawn from the US market by the manufacturer in October, 2010 due to clinical trial data indicating an increased risk of heart attack and stroke. The following dosage information applies to when the drug was available in the US.
Initial Dose: 10 mg orally once a day.
Usual Geriatric Dose for Obesity
Sibutramine was voluntarily withdrawn from the US market by the manufacturer in October, 2010 due to clinical trial data indicating an increased risk of heart attack and stroke. The following dosage information applies to when the drug was available in the US.
Clinical studies of sibutramine did not include sufficient numbers of patients over 65 years of age. Sibutramine is contraindicated in this group of patients.
Usual Pediatric Dose for Obesity
Sibutramine was voluntarily withdrawn from the US market by the manufacturer in October, 2010 due to clinical trial data indicating an increased risk of heart attack and stroke. The following dosage information applies to when the drug was available in the US.
Based on one study (n=60)
14 to 17 years:
Initial Dose: 10 mg orally once a day.
The recipe of sibutramine(Making by yourself)
About sibutramine hydrochloride Customers use feedback solutions(The recipe is for reference only):
1. Our products are sibutramine hydrochloride, purity 99%, pharmaceutical grade.
2. The commonly used method in the market is
1). Mixed sweet potato leaves, lotus leaves, coffee powder and other plant extracts, such plant extracts are alkaline substances, with sibutramine hydrochloride mixed use, acid-base neutralization, reduce or lead to product weight loss effect instability.
2). Direct use of sibutramine hydrochloride, each capsule content 20-30mg, daily dose not exceed 200mg.
3). From the pharmacy, it is recommended that the use of grape sugar and sibutramine hydrochloride mixed capsules, recommended dose 30mg.
3. Recommendations on the production of equipment:
1). The use of air pressure filling equipment to ensure that the net content of each capsule to achieve the specified value.
2). The use of mechanical mixing equipment to ensure that the drug and other accessories fully mixed.
4. With regard to testing
Customers are recommended to use our products directly in the third-party laboratory or Annex University chemical laboratory testing, with a test report, can be reimbursed for testing costs and sample costs.
Sibutramine treat obesity(Sibutramine's application field)
Even if sibutramine has serious side effects, it is still a lot of weight loss products manufacturers, the most important raw materials in use, such as weight loss coffee, diet drink, jelly, etc., to lose weight is inseparable from the use of sibutramine.Adding proper sibutramine powder in these products can help improve the timeliness of medicine and help customers to achieve the desire to lose weight.
How sibutramine works in treating obesity?
Sibutramine(Meridia) has a direct influence on the brain as the very first step after the taking Meridia. As the nervous system acts as the center for controlling all the physical activities in the body, it becomes essential for the pill to propel its action in the brain. Meridia interacts with the chemicals in the nervous system that have a direct impact on the weight of the body.
The pill is suggested by experts to be taken as a blend with the daily diet to see the actual results within a specified time frame. Obesity is found to lead to other problems like spike in blood pressure, and other health issues like diabetes. The diet intake should be of low calorie along with an appropriate exercise regimen.
How effective is sibutramine in treating obesity?
Sibutramine(Meridia) is found to be highly effective in the treatment of obesity as the medication is able to bring down the additional flab in the body in a gradual way spread over a period of time. If the weight loss program is accompanied by a proper diet and right medication like Meridia it leads to a definite reduction in body weight and also opens up the clear passage of healthy life. Obesity is a commonly reported problem affecting many people and it’s also understood by the patients how difficult it is shed the excess weight. When the body has excess weight it becomes a persisting problem for the individual to perform even simple tasks. With obesity as the main ailment, other issues also step into the body and make the affected person suffer on the whole.
Pay attention on 3 things when making Diet Tea or others
Like this situation, it is said that not only in Singapore, there are many countries in Europe and North America, consumer reaction side effects, the actual effect is not obvious, were found to contain sibutramine, therefore, make the weight loss products manufacturers did not notice the control, the side effects of product after adding sibutramine not grasp good production proportion.
Here, we have to remind manufacturers of weight loss products (diet tea, weight loss coffee, diet jelly, etc.) that manufacturers should pay attention to the following issues:
1. Control the degree of acid and alkali of the product, so as to prevent the salt from being turned into salt in the acid base, resulting in the invalid product;
2. Sibutramine can not be mixed with plant extracts, plant extracts are generally strong alkaline, while sibutramine is strongly acidic, and it will also become salt after blending.
3. If you do not add other recipes properly, you will have obvious side effects: constipation, stain on your face, bad breath, etc.
Sibutramine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using sibutramine and call your doctor at once if you have a serious side effect such as:
- fast, pounding, or uneven heartbeats;
- new or worsening shortness of breath;
- agitation, hallucinations, fever, tremor, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, dilated pupils;
- very stiff (rigid) muscles, high fever, sweating, confusion, feeling like you might pass out;
- easy bruising or bleeding (nosebleeds, bleeding gums, or any bleeding that will not stop);
- dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, seizure);
- chest pain or heavy feeling, pain spreading to the arm or shoulder, general ill feeling; or
- sudden numbness or weakness (especially on one side of the body), problems with vision, speech, or balance.
What should I avoid while taking sibutramine(Warning of sibutramine)?
Sibutramine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Do not take any other prescription or over-the-counter weight-loss products without your doctor's advice.
Avoid taking cough and cold or allergy medications while taking sibutramine.
Avoid drinking alcohol while taking sibutramine.
Sibutramine price
The price of sibutramine in the market is relatively expensive, especially for capsules and tablets, which will add a variety of materials to make, making its own value and price are out of proportion.
It is reasonable to choose the high purity of sibutramine powder, the powder is easy to test the purity, and can quickly distinguish the value of it.So sibutramine powder may be a better choice for users.
Here give a reference value，In general，sibutramine：USD50/10g,USD160/100g.
Buy sibutramine powder online
Visit our online pharmacy (AASRAW)and fill in an order of Meridia (Sibutramine). Define place of delivery, quantity of the product and the way of payment. In the period of 30 minutes, you will receive a confirmation of your order. It will be delivered within 10 business days.
100% Quality. We work only with licensed and reliable suppliers, which allow us to offer you best quality products at a very good price. Any product we offer (brand or generic) is a product which gained a very good reputation among our customers and was acknowledged by FDA.
Online order status check. We offer our customers a very convenient option to receive an update on order status. You can see the progress of your order beginning from the placement up to the delivery. Moreover you can contact our 24/7 support and receive any information you need without going online.
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We are able to ship to the following countries: United States, Canada, UK (Great Britain), Australia, Belgium, Denmark, Finland, France, Greece, Ireland, Italy, Spain.ect.
We have a guaranteed delivery. The standard shipping period takes from 14 to 28 business days. The order will be shipped via Registered airmail.
In case of any problems with the order we will offer you a free of charge re-shipment or a full refund of the amount.
More please read web site:www.aasraw.com.
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