Clomiphene citrate raw powder: Is it possible to get pregnancy fast by Clomiphene citrate?
What is Clomiphene citrate?
Clomiphene citrate is a non-steroidal fertility medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation (the release of an egg from the ovary).
Clomiphene citrate is used to cause ovulation in women with certain medical conditions (such as polycystic ovary syndrome) that prevent naturally occurring ovulation.Clomiphene citrate may also be used for purposes not listed in this medication guide.
You know: Clomiphene citrate mechanism of action
Clomiphene citrate was recently reclassified as a selective-estrogen receptor-modulator (SERM) due to its ability to compete with estradiol for estrogen receptors at the level of the hypothalamus. Clomiphene citrate blocks the normal negative feedback of circulating estradiol on the hypothalamus, preventing estrogen from lowering the output of gonadotropin releasing hormone (GnRH). During Clomiphene citrate therapy, the frequency and amplitude of GnRH pulses increase and stimulate the pituitary gland to release more FSH and LH. In turn, FSH and LH stimulate the ovaries to develop oocyte follicles. Clomiphene citrate may allow several oocytes to develop to maturity in some patients. Estrogen produced by the maturing follicles causes the cervical mucus to thin and the endometrium to proliferate. As the estradiol from these follicles rises, the positive feedback to the pituitary causes the FSH/LH surge and is followed by mature oocyte release (ovulation). Once ovulation occurs, the corpus luteum forms, and progesterone levels rise as they do in a regular ovulatory cycle, and prepare the endometrium for implantation. Clomiphene citrate must be used before the time of normal selection of the dominant follicle in an ovulatory cycle. The "traditional" timing of Clomiphene citrate treatment is from follicular phase cycle day 5 through 9; women typically ovulate 5—10 days after the last dose of the cycle. However, earlier initiation of treatment, longer courses (i.e., up to 10 days), or higher Clomiphene citrate doses may be needed dependent on the ovulatory response of the individual woman.
Clomiphene citrate is also a weak estrogen-agonist and may interact with estrogen-receptor containing tissues, including the ovary, endometrium, vagina, and cervix. In the cervix, Clomiphene citrate can interfere with the ability of cervical mucus glands to produce thin secretions that favor sperm motility and conception. In some women, Clomiphene citrate may induce dry, thick cervical secretions. Studies are ongoing to assess the activity of Clomiphene citrate on breast tissues. The estrogenic effects of Clomiphene citrate are secondary to the primary effects on hypothalamic-pituitary-ovarian function. Clomiphene citrate exhibits no androgenic, anti-androgenic, or progestational effects, nor does it affect pituitary-thyroid or pituitary-adrenal function. After Clomiphene citrate therapy discontinuation, there is usually no continued pharmacological effect on subsequent menstrual cycles. However, in some females, spontaneous ovulation has continued.
In selected female patients, Clomiphene citrate therapy is augmented by other medications to increase the occurrence of successful ovulation or pregnancy. These medications have included: dexamethasone for hirsutism or hyperandrogenism; estradiol to offset the cervical mucus-thickening effect of Clomiphene citrate; human chorionic gonadotropin (HCG) to induce the LH-surge for ovulation; and the use of metformin or troglitazone to offset the hyperinsulinemia that occurs in some patients with polycystic ovaries. Octreotide has been used as an adjunct to Clomiphene citrate therapy in patients with polycystic ovaries in order to reduce androgen secretion, decrease LH levels, and potentially decrease the incidence of ovarian hyperstimulation. The mechanisms of action of these drugs are distinct from Clomiphene citrate and do not appear to change the pharmacokinetics of clomiphene treatment. The regimens of each of these augmenting medications requires careful monitoring and timing of administration under the prescription of a healthcare professional experienced in fertility and endocrinology.
In men with idiopathic oligospermia, Clomiphene citrate may be effective at stimulating GnRH release from the hypothalamus, thus increasing the levels of LH and FSH released from the pituitary. LH and FSH then apparently stimulate the testicles to produce testosterone and sperm. Sperm volume and density are increased; however, Clomiphene citrate may not increase sperm maturation or motility.
The most important information: dosage of Clomiphene citrate
Usual Adult Dose for Ovulation Induction:
50 mg orally once a day for 5 days. Therapy should be initiated on or near the 5th day of the menstrual cycle, but may be started at any time in patients without recent uterine bleeding.
If ovulation occurs and pregnancy is not achieved, up to 2 additional courses of Clomiphene citrate 50 mg orally once a day for 5 days may be administered. Each subsequent course may be started as early as 30 days after the previous course and after pregnancy has been excluded.
Most patients ovulate following the first course of therapy. However, if the patient fails to ovulate, a second course of 100 mg/day for 5 days may be given as early as 30 days following the initial course. A third course of 100 mg/day for 5 days may be given after 30 days, if necessary.
Treatments beyond three cycles of Clomiphene citrate, dosages greater than 100 mg once a day, and/or course durations beyond 5 days are not recommended by the manufacturer. However, successful pregnancies and term deliveries have been reported in women receiving up to 200 mg/day for 5 days, or extended 10-day course of therapy, or consecutive cycles of treatment beyond the 3 recommended by the manufacturer.
Usual Adult Dose for Lactation Suppression:
50 to 100 mg orally once a day for 5 days. Generally, one course of therapy is sufficient.
Usual Adult Dose for Oligospermia:
25 to 100 mg orally once a day. Therapy is generally given over a period of several months.
How should I take Clomiphene citrate?
Use Clomiphene citrate exactly as directed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Your doctor will perform medical tests to make sure you do not have conditions that would prevent you from safely using Clomiphene citrate.Clomiphene citrate is usually taken for 5 days, starting on the 5th day of your menstrual period. Follow your doctor's instructions.
You will need to have a pelvic examination before each treatment cycle. You must remain under the care of a doctor while you are using this medicine.You will most likely ovulate within 5 to 10 days after you take Clomiphene citrate. To improve your chance of becoming pregnant, you should have sexual intercourse while you are ovulating.
Your doctor may have you take your temperature each morning and record your daily readings on a chart. This will help you determine when you can expect ovulation to occur.
Attention! Clomiphene citrate side effects
Get emergency medical help if you have any signs of an allergic reaction to Clomiphene citrate: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some women using this medicine develop a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment. OHSS can be a life threatening condition. Call your doctor right away if you have any of the following symptoms of OHSS:
- stomach pain, bloating;
- nausea, vomiting, diarrhea;
- rapid weight gain, especially in your face and midsection;
- little or no urinating; or pain when you breathe, rapid heart rate, feeling short of breath (especially when lying down).
Stop using Clomiphene citrate and call your doctor at once if you have:
- pelvic pain or pressure, enlargement in your pelvic area;
- vision problems;
- seeing flashes of light or "floaters" in your vision;
- increased sensitivity of your eyes to light; or heavy vaginal bleeding.
Common Clomiphene citrate side effects may include:
- flushing (warmth, redness, or tingly feeling);
- breast pain or tenderness;
- headache; or breakthrough bleeding or spotting.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How to get pregnant fast on Clomiphene citrate?
Step 1
To get pregnant fast with Clomid, you need to visit your doctor for a prescription. Doctors routinely prescribe Clomid to patients who can't get pregnant, so you shouldn't have any trouble finding one who will comply. Some doctors only prescribe Clomid if you have been trying to achieve pregnancy for a year or more. That way it shows that you are truly having issues with fertility. If you admit you have been trying to get pregnant for less time, you will probably get the "slow down, give it some time, and it will happen" speech.
Step 2
Ask for the generic of Clomid, clomiphene citrate, when you fill the prescription at the pharmacy. Clomid is probably not covered by your insurance since it's a fertility aid, so you want to save some money here and get the cheaper version. Drugs are not like clothes – the name brand and the knock off are the same exact thing. Clomiphene citrate will work just as well as Clomid so you can get pregnant fast, and it will cost between $25 and $50 a cycle, depending on your dosage. Brand name Clomid would cost much more.
Step 3
Take one pill on Day 3 through Day 7 of your menstrual cycle. (Some doctors may say to take it on Day 5 through Day 9, but most people who have success and get pregnant took Clomid on Day 3 through Day 7. Discuss it with your doctor if you're concerned, but it's really just a matter of preference. Neither will harm you.) Make sure what you are calling Day 1 of your cycle is true bleeding, not just the spotting that occurs before the full blown period starts. The most common dosage of Clomid is 50mg.
Step 4
Turn down the multiple ultrasounds to save money. Your doctor may want you to come in daily around ovulation to see how your ovaries are responding. This can be very helpful, but it is extremely expensive and again, insurance doesn't cover it. Ask politely if you can skip the ultrasounds this month due to cost. The ultrasounds won't help you get pregnant, but they will show your doctor if the Clomid is doing its job. If cost and time aren't issues, then go for it. The ultrasound tech will be able to tell you how many viable eggs you have, and the more viable eggs, the more of a chance of pregnancy.
Step 5
Have intercourse every other day starting on Day 7. Men need about 48 hours to really build up enough sperm in their systems to easily get you pregnant. They can go two days in a row ONE TIME, and then after that, the sperm will start dwindling in numbers. Having sex every day of your cycle is a bad idea and will not help you get pregnant fast. In fact, you may not get pregnant after multiple cycles if you do.
Step 6
Start checking your cervical mucus on Day 10 of your cycle to see if it's time to try to get pregnant. Cervical mucus (CM) should be wet and stringy, and of an egg white consistency. When the egg white CM (cervical mucus) starts, ovulation is imminent. Clomid has a tendency to dry up cervical mucus a little bit, so some people recommend taking Guaifenesin (Robitussin makes a product, but the generic is cheaper) each day from Day 10 to Day 16 to make the CM (cervical mucus) more favorable to sperm. It probably isn't necessary, but it can't hurt.
Step 7
Start using an ovulation predictor kit on Day 10 as well. With both the ovulation predictor kit and the CM (cervical mucus) check, you should have a very good idea of when you are ovulating, and that knowledge will help you get pregnant fast! Once the kit says you are ovulating, have intercourse that day and the next day. This is the one time you get to have sex two days in a row. Then go back to every other day for as long as you'd like (at least 8 days after the positive.)
Step 8
Take a pregnancy test on or after Day 28 if you want an accurate results. Why make yourself crazy with testing every day (even though you're dying to know!)? If you are pregnant, it will show up on a stick on Day 28. Best wishes on making your bundle of joy happen!
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